KWIATKOWSKI LABORATORY
![Home](http://www.kwiatkowskilab.org/wp-content/plugins/revslider/public/assets/assets/dummy.png)
A plot of all subjects (left to right) with their respective responses,
histology, and mutations is shown.
Taken from: Kwiatkowski DJ et al. Mutations in TSC1, TSC2, and MTOR
Are Associated with Response to Rapalogs in Patients with Metastatic
Renal Cell Carcinoma. Clinical Cancer Research 2016
![Home](http://www.kwiatkowskilab.org/wp-content/plugins/revslider/public/assets/assets/dummy.png)
cancer. Taken from Kim et al. “Invasive Bladder Cancer: Genomic
Insights and Therapeutic Promise”. Clinical Cancer Research 2015
![Home](http://www.kwiatkowskilab.org/wp-content/plugins/revslider/public/assets/assets/dummy.png)
Molecular Basis of Giant Cells in Tuberous
Sclerosis Complex New England Journal of
Medicine 2014
![Home](http://www.kwiatkowskilab.org/wp-content/plugins/revslider/public/assets/assets/dummy.png)
events as the cause of multifocal renal cell carcinoma
in tuberous sclerosis complex”. Human Molecular Genetics 2015
![Home](http://www.kwiatkowskilab.org/wp-content/plugins/revslider/public/assets/assets/dummy.png)
with mutant allele frequency ranging from 0.21% to 34%,
including two with 0% frequency
-17 subjects had mosaicism with mutant AF < 5%:
5 indel, 5 nonsense, 2 splice site, 2 missense, and 3 genomic deletion mutations